Eosinophilic Esophagitis (EoE)

Eosinophilic Esophagitis (EoE) is a chronic immune system disease that causes inflammation in the esophagus. It occurs when a large number of eosinophils, a type of white blood cell, build up in the lining of the esophagus as a response to allergens, food, or environmental triggers. This can lead to difficulty swallowing, food impaction, and esophageal damage over time. EoE is considered a rare condition but has become more commonly diagnosed in recent years.

What is Eosinophilic Esophagitis (EoE)?

Eosinophilic Esophagitis is a condition where the esophagus becomes inflamed due to an overproduction of eosinophils. This buildup is often triggered by allergens in food or the environment. The inflammation can make it difficult for food to pass through the esophagus, leading to symptoms such as difficulty swallowing and food getting stuck in the throat.

Types of EoE

There is no strict classification for EoE types, but the condition can be divided based on the severity of symptoms and the level of eosinophilic infiltration in the esophagus. It is often seen in conjunction with other allergic conditions like asthma, eczema, and seasonal allergies.

How Common is EoE?

Eosinophilic Esophagitis (EoE) is relatively rare but has been increasing in prevalence over the past decade, especially in children and young adults. It is more common in males than females and often presents in individuals who have other allergic conditions.

Common Symptoms

  • Difficulty swallowing (dysphagia)
  • Food getting stuck in the esophagus (food impaction)
  • Chest pain or heartburn
  • Persistent throat pain or irritation
  • Nausea or vomiting
  • Failure to thrive in children due to difficulty eating

Common Causes

  • Allergic Reactions: EoE is often triggered by allergic reactions to certain foods, such as dairy, wheat, eggs, soy, or nuts. Environmental allergens like pollen can also be a contributing factor.
  • Immune Response: EoE is an immune-mediated disease, where eosinophils accumulate in the esophagus in response to specific allergens or irritants.
  • Genetic Factors: A family history of EoE or other allergic conditions may increase the risk of developing the disease.

FAQs

Common food triggers include dairy, wheat, soy, eggs, nuts, and seafood. An elimination diet or allergy testing can help determine which foods you should avoid.

EoE is diagnosed through an upper endoscopy with biopsies of the esophagus to check for an elevated number of eosinophils. Allergy testing is also commonly used to identify triggers.

There is no cure for EoE, but it can be managed with dietary changes, medications such as corticosteroids, and avoidance of known allergens.

Treatment may involve dietary modifications, swallowed topical corticosteroids to reduce inflammation, proton pump inhibitors, and, in severe cases, esophageal dilation to relieve strictures caused by scarring.

Yes, people with EoE often have other allergic conditions such as asthma, eczema, or seasonal allergies. These conditions may share common immune system pathways, contributing to the development of EoE.

Abdominal pain, food getting stuck in your esophagus, nausea, and regurgitation are a few common symptoms of Eosinophilic Esophagitis but your symptoms may be different depending on when you develop the disease:

  • A baby or toddler may vomit, refuse to eat, or have issues with gaining weight (failure to thrive).
  • Older children and adults may have dysphagia, heartburn, or chest discomfort.

Not exactly! While EoE is often triggered by specific foods, it’s different from typical food allergies. EoE is an immune reaction that causes eosinophils, a type of white blood cell, to build up in the esophagus, leading to inflammation. Identifying trigger foods can help manage symptoms, but EoE is a unique condition that requires specialized treatment.

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